Quantitative Analysis of Synthetic Gene Delivery Vector Design Properties

Targeted synthetic gene delivery vectors.

Synthetic gene delivery vehicles have made significant progress in the past decade in demonstrating strong potential for targeted delivery to specific cells, low toxicity and immunogenicity and large carrying capacity. However, significant advances must still be made to increase the efficiency of both polymer and lipid vehicles. Furthermore, techniques to generate more effective targeting moiet...

Cloning of synthetic gene including antigens against Urinary Tract Infections in pET28a+ vector

There are many different bacterial infections in the world that patients are suffering from and research teams are trying to find suitable ways to prevent and treat them. Urinary Tract Infections (UTIs) are most important infections in the world , and they are more common among women because vaginal cavity is near to urethral opening. The aim of this study is cloning of synthetic gene include a...

Targeting of Synthetic Gene Delivery Systems

Safe, efficient, and specific delivery of therapeutic genes remains an important bottleneck for the development of gene therapy. Synthetic, nonviral systems have a unique pharmaceutical profile with potential advantages for certain applications. Targeting of the synthetic vector improves the specificity of gene medicines through a modulation of the carriers' biodistribution, thus creating a dos...

Quantitative modeling of synthetic gene transfer

Synthetic Vector Analysis III From Vector Analysis to Differential Forms

In our previous paper [International Journal of Theoretical Physics, 41 (2002), 1165-1190] we have shown, following the tradition of synthetic differential geometry, that div and rot are uniquely determined, so long as we require that the divergence theorem and the Stokes theorem should hold on the infinitesimal level. In this paper we will simplify the discussion considerably in terms of diffe...